Description

n-(6-Chloro-3-Formyl-Pyridin-2-Yl)-2,2-Dimethyl-Propionamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyridine-based molecular architecture. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a key chiral building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its chloropyridine moiety.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the life sciences sector.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	n-(6-Chloro-3-Formyl-Pyridin-2-Yl)-2,2-Dimethyl-Propionamide
CAS No.	127446-34-8
Molecular Formula	C11H13ClN2O2
Molecular Weight	240.69 g/mol
Synonyms	2,2-Dimethyl-N-(6-chloro-3-pyridinylcarbonyl)propanamide; 6-Chloro-3-formyl-2-pyridinecarboxamide, N-(1,1-dimethylethyl)-; Pivalamide, N-(6-chloro-3-formyl-2-pyridinyl)-; 2-Pyridinecarboxamide, 6-chloro-3-formyl-N-(1,1-dimethylethyl)-; N-(6-Chloro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide; 127446-34-8; 6-Chloro-3-formyl-N-(tert-butyl)picolinamide
EINECS	Contact for details

Quality Control

Our n-(6-Chloro-3-Formyl-Pyridin-2-Yl)-2,2-Dimethyl-Propionamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.