Description

Methyl 2-(Benzyloxycarbonylamino)-2-Hydroxyacetate is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is essential for the controlled introduction of functionalized amino acid motifs, enabling the production of complex molecules with high stereochemical fidelity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected serine or glycine derivatives.
• Chemical Biology Research: Employed in the design and synthesis of enzyme substrates, inhibitors, and molecular probes.
• API Development: Serves as a building block for constructing the core scaffolds of potential therapeutic candidates.
• Asymmetric Synthesis: Utilized in reactions requiring a protected amino acid ester with a free hydroxyl group for further functionalization.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.

Basic Information

Product Name	Methyl 2-(Benzyloxycarbonylamino)-2-Hydroxyacetate
CAS No.	127357-38-4
Molecular Formula	C11H13NO5
Molecular Weight	239.23 g/mol
Synonyms	Methyl N-Cbz-glycinate derivative; Methyl (benzyloxycarbonylamino)(hydroxy)acetate; Z-Amino(hydroxy)acetic acid methyl ester; N-Carbobenzoxy-2-hydroxyglycine methyl ester; (Benzyloxycarbonylamino)(hydroxy)acetic acid methyl ester; 2-[(Benzyloxy)carbonylamino]-2-hydroxyacetic acid methyl ester; Methyl 2-hydroxy-2-[(phenylmethoxy)carbonylamino]acetate
EINECS	Contact for details

Quality Control

Our Methyl 2-(Benzyloxycarbonylamino)-2-Hydroxyacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.