Description

Zamifenacin CAS NO 127263-13-2 is a selective muscarinic M3 receptor antagonist, a compound of significant interest in pharmacological research and development. Its primary value lies in its potential therapeutic applications for conditions involving smooth muscle hyperactivity, such as overactive bladder and irritable bowel syndrome. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and companies developing novel antimuscarinic agents.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of new antimuscarinic drugs.
• Mechanism of Action Studies: Used in preclinical research to investigate the role and function of muscarinic M3 receptors in various physiological systems.
• Bioactivity Screening: Serves as a positive control or active compound in high-throughput screening assays for receptor binding and functional activity.
• Metabolism and Pharmacokinetics (DMPK): Employed in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profiles of M3 antagonists.
• Analytical Method Development: Used as a certified reference material (CRM) for developing and validating analytical methods like HPLC and LC-MS.
• Academic Teaching & Advanced Studies: A compound of interest in university laboratories for teaching medicinal chemistry and receptor pharmacology principles.

Basic Information

Product Name	Zamifenacin
CAS No.	127263-13-2
Molecular Formula	C23H26N2O3S
Molecular Weight	410.53 g/mol
Synonyms	Zamifenacin; UK-76,654; (3R)-1-[2-(4-{[(2S)-2-Cyclohexyl-2-hydroxy-2-phenylacetyl]oxy}-1-piperidinyl)ethyl]-3-(phenylsulfonyl)-2,3-dihydro-1H-benzimidazol-2-one; UK 76654; UK76654
EINECS	Contact for details

Quality Control

Every batch of Zamifenacin is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in research and development, ensuring identity, purity, and consistency. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.