Description

Carbamic Acid, (2-Fluorocyclopropyl)-, 1,1-Dimethylethyl Ester, (1S-Cis)- (9Ci) is a high-purity, stereochemically defined fluorinated cyclopropane derivative. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of novel active ingredients. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring structurally complex, fluorinated scaffolds.

Application

• As a key chiral intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• In medicinal chemistry research for constructing fluorinated cyclopropane motifs to modulate drug potency, metabolic stability, and bioavailability.
• For the development of protease inhibitors and other enzyme-targeted therapies where the fluorocyclopropyl group is a key pharmacophore.
• As a specialized reagent in asymmetric synthesis and process chemistry for scale-up production.
• In agrochemical research for creating novel compounds with enhanced biological activity.

Basic Information

Product Name	Carbamic Acid, (2-Fluorocyclopropyl)-, 1,1-Dimethylethyl Ester, (1S-Cis)- (9Ci)
CAS No.	127199-15-9
Molecular Formula	C9H16FNO2
Molecular Weight	189.23 g/mol
Synonyms	(1S-cis)-N-(tert-Butoxycarbonyl)-2-fluorocyclopropanamine; tert-Butyl (1S,2S)-2-fluorocyclopropylcarbamate; (1S,2S)-2-Fluorocyclopropylcarbamic acid tert-butyl ester; BOC-(1S,2S)-2-fluorocyclopropylamine; N-Boc-(1S,2S)-2-fluorocyclopropanamine; (1S,2S)-N-Boc-2-fluorocyclopropanamine; (1S,2S)-2-Fluorocyclopropanamine, N-Boc-protected
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the high standards required for pharmaceutical R&D and production. Comprehensive analytical data including HPLC, GC, NMR, and chiral analysis are documented. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.