Description

Trifluoromethanesulfonic Acid Diethylisopropylsilyl Ester is a highly versatile organosilicon reagent featuring a reactive silyl protecting group. This compound is valued for its role in sophisticated organic synthesis, particularly in the protection of sensitive functional groups and as a precursor in the synthesis of complex molecules. It is primarily sought by research and development laboratories, pharmaceutical intermediates manufacturers, and specialty chemical producers working on advanced materials, agrochemicals, and active pharmaceutical ingredients (APIs).

Application

• Protecting Group Reagent in multi-step organic synthesis for alcohols, phenols, and carboxylic acids.
• Intermediate for Pharmaceutical Synthesis, used in the preparation of complex drug candidates and APIs.
• Precursor in Material Science for the development of silicon-containing polymers and advanced coatings.
• Agrochemical Intermediate in the synthesis of novel herbicides and fungicides.
• Cross-coupling Reagent in palladium-catalyzed reactions for constructing carbon-silicon bonds.
• Nucleoside and Carbohydrate Chemistry for the selective protection of hydroxyl groups.

Basic Information

Product Name	Trifluoromethanesulfonic Acid Diethylisopropylsilyl Ester
CAS No.	126889-55-2
Molecular Formula	C8H17F3O3SSi
Molecular Weight	278.37 g/mol
Synonyms	Diethylisopropylsilyl Triflate; Diethylisopropylsilyl Trifluoromethanesulfonate; (Diethylisopropylsilyl) Triflate; DEIPS Triflate; (i-Pr)(Et)2SiOTf; Trifluoromethanesulfonic Acid (Diethylisopropylsilyl) Ester; Silylating Agent DEIPS-OTf
EINECS	Contact for details

Quality Control

Our Trifluoromethanesulfonic Acid Diethylisopropylsilyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system supports compliance with cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.