Description

(S)-Methyl 4-(tert-Butoxycarbonylamino)-5-Hydroxypentanoate is a high-value chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the production of complex pharmaceuticals, particularly in the synthesis of peptide-based drugs and enzyme inhibitors. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to construct specific stereocenters with high enantiomeric purity, ensuring the efficacy and safety of final active pharmaceutical ingredients (APIs). Its defined stereochemistry and protective groups provide critical control in multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of protease inhibitors, renin inhibitors, and other peptide-mimetic therapeutics.
• Peptide Chemistry: Serves as a protected hydroxy- and amino-functionalized building block for solid-phase and solution-phase peptide synthesis (SPPS).
• Asymmetric Synthesis: Used in the construction of complex natural products and bioactive molecules requiring the (S)-configuration at the α-carbon.
• API Development: Integral to research and process development for new chemical entities (NCEs) in preclinical and clinical stages.
• Bioconjugation: The reactive hydroxyl and protected amine groups allow for selective modification and linker attachment in prodrug design.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways.

Basic Information

Product Name	(S)-Methyl 4-(tert-Butoxycarbonylamino)-5-Hydroxypentanoate
CAS No.	126587-35-7
Molecular Formula	C11H21NO5
Molecular Weight	247.29 g/mol
Synonyms	(S)-Methyl 4-((tert-Butoxycarbonyl)amino)-5-hydroxypentanoate; (S)-Methyl 5-hydroxy-4-((tert-butoxycarbonyl)amino)pentanoate; Boc-L-Homoserine(OMe); Methyl (4S)-4-[(tert-butoxycarbonyl)amino]-5-hydroxypentanoate; (S)-4-(Boc-amino)-5-hydroxy-pentanoic acid methyl ester; L-Homoserine, N-Boc-, methyl ester; Boc-Hse(OMe)-OH; (S)-Methyl 4-(Boc-amino)-5-hydroxypentanoate
EINECS	Contact for details

Quality Control

Our (S)-Methyl 4-(tert-Butoxycarbonylamino)-5-Hydroxypentanoate is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, chiral analysis, NMR, and other relevant tests. Our commitment to cGMP principles and ISO 9001 standards ensures traceability and consistent quality for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is compatible with strong acid/organic solvent environments but should be kept under inert atmosphere for long-term storage to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.