Description

4-Methoxy-3-(Triisopropylsilyl)Pyridine is a high-value organosilicon-protected pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in the triisopropylsilyl (TIPS) protecting group, which offers superior steric bulk and stability for selective functionalization of the pyridine ring. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting the central nervous system or as kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require functionalized pyridine cores.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, conductive polymers, and other functional materials where electron-donating methoxy and bulky silyl groups modulate electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development in synthetic organic chemistry and heterocycle functionalization studies.

Basic Information

Product Name	4-Methoxy-3-(Triisopropylsilyl)Pyridine
CAS No.	126378-42-5
Molecular Formula	C16H29NOSi
Molecular Weight	279.50 g/mol
Synonyms	3-[(Triisopropylsilyl)oxy]-4-methoxypyridine; 4-Methoxy-3-(triisopropylsilyl)pyridine; 3-Triisopropylsilyl-4-methoxypyridine; Pyridine, 4-methoxy-3-(triisopropylsilyl)-; TIPS-Protected 4-Methoxypyridine; 4-Methoxy-3-(TIPS)pyridine
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(Triisopropylsilyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.