Description

Methanone, [2-(Methylamino)Phenyl](1,3,4,9-Tetrahydro-2H-Pyrido[3,4-B]Indol-2-Yl)- is a complex heterocyclic organic compound featuring a methanone (ketone) functional group bridging a substituted phenyl ring and a tetrahydro-β-carboline moiety. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate (API intermediate) and a key scaffold in medicinal chemistry research. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents targeting neurological and psychiatric disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates, particularly those with central nervous system (CNS) activity.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new molecules with optimized biological profiles.
• Biochemical Tool Compound: May be utilized in pharmacological assays to study receptor interactions and enzyme inhibition related to the β-carboline class of compounds.
• Reference Standard: Supplied as a high-purity compound for use as an analytical standard in quality control and method development within pharmaceutical analysis.
• Organic Synthesis: Employed in specialized organic synthesis for constructing complex nitrogen-containing heterocycles due to its unique fused ring system.

Basic Information

Product Name	Methanone, [2-(Methylamino)Phenyl](1,3,4,9-Tetrahydro-2H-Pyrido[3,4-B]Indol-2-Yl)-
CAS No.	126223-62-9
Molecular Formula	C23H23N3O
Molecular Weight	357.45 g/mol
Synonyms	2-(2-Methylaminobenzoyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole; [2-(Methylamino)phenyl](1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)methanone; 1,3,4,9-Tetrahydro-2-[[2-(methylamino)phenyl]carbonyl]-2H-pyrido[3,4-b]indole; Tetrahydro-β-carboline ketone derivative; Methylamino-phenyl-tetrahydro-β-carbolinyl methanone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from techniques such as HPLC, NMR, and mass spectrometry. We support cGMP-compliant manufacturing for pharmaceutical applications, ensuring full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.