Description

L-Proline, 4-Fluoro-, Methyl Ester, cis- (9Ci) is a high-purity, fluorinated proline derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the precise introduction of fluorine and the cis-configured proline scaffold, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, protease inhibitors, and other bioactive compounds where stereochemistry and fluorination are key design parameters.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated peptide drugs and enzyme inhibitors.
• Protease Inhibitor Synthesis: Used in constructing core structures for inhibitors targeting serine, cysteine, or metalloproteases.
• Peptidomimetics: Incorporation into peptide analogs to enhance metabolic stability, membrane permeability, and binding affinity.
• Chemical Biology Probes: Serves as a building block for fluorinated amino acid analogs used in studying protein structure and function.
• Agrochemical Research: Potential intermediate in the synthesis of novel, fluorinated bioactive compounds for crop protection.
• Asymmetric Catalysis: Can be utilized as a precursor for chiral ligands or organocatalysts in stereoselective transformations.

Basic Information

Product Name	L-Proline, 4-Fluoro-, Methyl Ester, cis- (9Ci)
CAS No.	126111-12-4
Molecular Formula	C7H10FNO2
Molecular Weight	159.16 g/mol
Synonyms	cis-4-Fluoro-L-proline methyl ester; Methyl cis-4-fluoro-L-prolinate; (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid methyl ester; L-Proline, 4-fluoro-, methyl ester, cis-; 4-Fluoro-L-proline methyl ester (cis); Fluoroproline methyl ester; F-Pro-OMe (cis); (4S)-Fluoro-L-proline methyl ester (cis)
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Fluoro-, Methyl Ester, cis- (9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.