Description

L-Proline, 4-(Methylthio)-, Methyl Ester, cis- (9Ci) is a specialized, non-proteinogenic proline derivative characterized by a cis-configuration and a methylthio substituent at the 4-position. This compound serves as a high-value chiral building block and intermediate in advanced organic synthesis, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, peptidomimetics, and asymmetric catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptide-based therapeutic programs.
• Peptidomimetics Research: Used to introduce constrained, sulfur-containing proline analogs into peptide chains to study structure-activity relationships and enhance metabolic stability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Chemical Biology Probes: Incorporated into probe molecules for investigating enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Serves as an intermediate in the synthesis of advanced, biologically active compounds for crop protection.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for creating custom compound libraries.

Basic Information

Product Name	L-Proline, 4-(Methylthio)-, Methyl Ester, cis- (9Ci)
CAS No.	126111-07-7
Molecular Formula	C7H13NO2S
Molecular Weight	175.25 g/mol
Synonyms	cis-4-(Methylthio)-L-proline methyl ester; Methyl cis-4-(methylthio)-L-prolinate; L-Proline, 4-(methylthio)-, methyl ester, (4S)-; (2S,4S)-1-Methyl 4-(methylthio)prolinate; 4-Methylthio-L-proline methyl ester (cis); (4S)-4-(Methylsulfanyl)-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Methylthio)-, Methyl Ester, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.