Description

4-(3,5-Bis-Trimethylsilanyl-Benzoylamino)-Benzoic Acid Methyl Ester is a specialized organosilicon-protected intermediate of significant value in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel chemical entities and protecting sensitive functional groups during multi-step syntheses.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds requiring protected amine and carboxylic acid functionalities.
• Peptide Mimetic Research: Used in the development of peptidomimetics and other bioactive molecules where the trimethylsilyl groups provide steric protection and influence pharmacokinetic properties.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor in the creation of advanced organic electronic materials and liquid crystal compounds, leveraging its rigid, substituted aromatic structure.
• Agrochemical Development: Employed in the research and synthesis of new generation herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Protecting Group Strategy: Utilized in multi-step synthetic routes where the silyl groups protect reactive sites, allowing for selective transformations elsewhere in the molecule.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in methodological chemistry and novel compound library development.

Basic Information

Item	Detail
Product Name	4-(3,5-Bis-Trimethylsilanyl-Benzoylamino)-Benzoic Acid Methyl Ester
CAS No.	125973-71-9
Molecular Formula	C22H31NO3Si2
Molecular Weight	413.66 g/mol
Synonyms	Methyl 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoate; 4-(3,5-Bis(trimethylsilyl)benzamido)benzoic acid methyl ester; Benzoic acid, 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-, methyl ester; Methyl 4-(3,5-bis(trimethylsilyl)benzamido)benzoate; 4-(3,5-Bis-trimethylsilanyl-benzoylamino)-benzoic acid methyl ester; 125973-71-9; 4-[(3,5-Bis(trimethylsilyl)benzoyl)amino]benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-(3,5-Bis-Trimethylsilanyl-Benzoylamino)-Benzoic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; ensure the container is kept tightly sealed in a dry environment to prevent hydrolysis of the silyl protecting groups. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.