Description

Ethyl (S)-2-Hydroxy-4-Phenylbutyrate is a high-value chiral intermediate, specifically the (S)-enantiomer, characterized by its phenylbutyrate ester structure. This compound is critically important for its role in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly angiotensin-converting enzyme (ACE) inhibitors. It is an essential building block for pharmaceutical manufacturers, fine chemical producers, and advanced research institutions focused on enantioselective synthesis and drug development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the production of ACE inhibitor drugs such as Benazepril, Cilazapril, and other related cardiovascular medications.
• Asymmetric Synthesis: Used as a starting material or resolving agent in stereoselective chemical reactions to introduce the desired (S)-configuration into target molecules.
• Fine Chemical Production: Employed in the manufacture of other high-purity, specialized chemicals requiring the (S)-2-hydroxy-4-phenylbutyrate moiety.
• Research & Development: Serves as a standard or reagent in academic and industrial R&D for method development in chiral chemistry and pharmacokinetic studies.
• Agrochemical Synthesis: Potential application as an intermediate in the synthesis of certain chiral agrochemicals and plant growth regulators.

Basic Information

Product Name	Ethyl (S)-2-Hydroxy-4-Phenylbutyrate
CAS No.	125639-64-7
Molecular Formula	C12H16O3
Molecular Weight	208.25 g/mol
Synonyms	(S)-Ethyl 2-Hydroxy-4-phenylbutanoate; (S)-2-Hydroxy-4-phenylbutyric Acid Ethyl Ester; Ethyl (S)-(-)-2-Hydroxy-4-phenylbutyrate; (S)-HPBE; (S)-Ethyl 2-Hydroxy-4-phenylbutyrate; (S)-α-Hydroxybenzenebutanoic Acid Ethyl Ester; (S)-2-Hydroxy-4-phenylbutanoic Acid Ethyl Ester; L-2-Hydroxy-4-phenylbutyric Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl (S)-2-Hydroxy-4-Phenylbutyrate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with pharmaceutical-grade standards. We provide comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess (ee), and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable and consistent material for critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	-20° to -24° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.