Description

4-(tert-Butyldimethylsiloxy)-3A,4,7,7A-Tetrahydrobenzo(B)Thiphen-3(2H)-One is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxyl group. This compound is critical for synthetic chemists requiring precise stereochemistry and functional group manipulation in complex molecule assembly. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly within the agrochemical and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and novel therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides requiring specific stereochemical configurations.
• Organic Synthesis Reagent: Serves as a versatile synthon for introducing the tetrahydrobenzo[b]thiophene scaffold into target molecules.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new chiral catalysts.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and specialty polymers.

Basic Information

Product Name	4-(tert-Butyldimethylsiloxy)-3A,4,7,7A-Tetrahydrobenzo(B)Thiphen-3(2H)-One
CAS No.	125507-51-9
Molecular Formula	C16H28O2SSi
Molecular Weight	312.55 g/mol
Synonyms	4-[(1,1-Dimethylethyl)dimethylsilyl]oxy-3a,4,7,7a-tetrahydro-1-benzothiophen-3(2H)-one; 4-(tert-Butyldimethylsilyloxy)-3a,4,7,7a-tetrahydrobenzo[b]thiophen-3(2H)-one; 4-(TBDMSO)-3a,4,7,7a-tetrahydrobenzo[b]thiophen-3-one; 3a,4,7,7a-Tetrahydro-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-benzothiophen-3(2H)-one; TBDMS-protected tetrahydrobenzothiophenone; CAS 125507-51-9
EINECS	Contact for details

Quality Control

Our production of 4-(tert-Butyldimethylsiloxy)-3A,4,7,7A-Tetrahydrobenzo(B)Thiphen-3(2H)-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.