Description

Bapta-Tetramethyl Ester CAS NO 125367-34-2 is a high-purity, cell-permeable ester derivative of the calcium chelator BAPTA, designed for precise intracellular calcium buffering in research applications. This compound is critical for researchers requiring controlled manipulation of cytosolic calcium levels without interfering with extracellular signaling. It is an essential tool for cell biologists, neuroscientists, and pharmacologists working in fields such as signal transduction, neurobiology, and cardiovascular research.

Application

• Intracellular Calcium Chelation: Used as a membrane-permeable precursor for loading cells with the calcium-specific chelator BAPTA to buffer and control free calcium ion concentrations.
• Signal Transduction Research: Essential for studying calcium-dependent processes, including enzyme activation, neurotransmitter release, and muscle contraction mechanisms.
• Neuroscience and Neuropharmacology: Applied in investigations of synaptic plasticity, neuronal excitability, and the role of calcium in neurodegenerative diseases.
• Cardiovascular Research: Utilized to examine calcium handling in cardiac myocytes and smooth muscle cells, relevant to arrhythmia and contractility studies.
• Cell Physiology Studies: Employed to probe the role of calcium in cell cycle progression, apoptosis (programmed cell death), and cellular metabolism.
• Fluorescent Probe Synthesis: Serves as a key synthetic intermediate for producing advanced, cell-permeable fluorescent calcium indicators.

Basic Information

Product Name	Bapta-Tetramethyl Ester
CAS No.	125367-34-2
Molecular Formula	C26H32N2O12
Molecular Weight	540.54 g/mol
Synonyms	BAPTA-AM Tetramethyl Ester; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetramethyl ester; BAPTA Tetra Methyl Ester; BAPTA TM Ester; BAPTA, Tetramethyl Ester; BAPTA-AM Precursor; BAPTA Tetramethyl Ester Acetoxymethyl Ester Analog; Tetramethyl 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
EINECS	Contact for details

Quality Control

Our Bapta-Tetramethyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive life science research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support research that may transition to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.