Description

2-Methylene-Pentanedioic Acid Di-tert-Butyl Ester is a high-purity, protected diacid derivative, serving as a versatile and reactive building block in advanced organic synthesis. Its core value lies in the tert-butyl ester protecting groups, which provide excellent stability for handling while allowing for selective deprotection under mild acidic conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for constructing complex molecular scaffolds, peptide mimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, including protease inhibitors and other biologically active molecules.
• Peptidomimetics & Conjugate Chemistry: Used to introduce a reactive methylene group and carboxylic acid functionality into peptide chains and bioconjugates after deprotection.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for creating specialized polyesters and functional polymers with tailored properties.
• Agrochemical Synthesis: Employed in the development of advanced herbicides and plant growth regulators requiring specific acid functionalities.
• Ligand & Catalyst Development: Serves as a precursor for chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & R&D: A valuable tool for medicinal chemistry and process research departments exploring new synthetic routes and molecular entities.

Basic Information

Product Name	2-Methylene-Pentanedioic Acid Di-tert-Butyl Ester
CAS No.	125010-32-4
Molecular Formula	C15H26O4
Molecular Weight	270.36 g/mol
Synonyms	2-Methylenepentanedioic Acid Di-tert-Butyl Ester; Di-tert-Butyl 2-Methylenepentanedioate; 2-Methyleneglutaric Acid Di-tert-Butyl Ester; Di-tert-Butyl 2-Methyleneglutarate; Glutaric Acid, 2-Methylene-, Di-tert-Butyl Ester; 2-Methylene-1,5-pentanedioic Acid Di-tert-Butyl Ester; tert-Butyl 2-Methyleneglutarate; (E)-Di-tert-butyl 2-methyleneglutarate
EINECS	Contact for details

Quality Control

Every batch of 2-Methylene-Pentanedioic Acid Di-tert-Butyl Ester is produced under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency through advanced techniques like HPLC, GC, and NMR. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.