Description

(R)-Ethyl 2-Azidopropanoate is a chiral, non-racemic organic compound featuring an azido functional group, serving as a versatile building block in asymmetric synthesis. Its primary value lies in its role as a key chiral precursor for the synthesis of unnatural amino acids, β-lactams, and other nitrogen-containing bioactive molecules. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical industries, particularly for medicinal chemists and process development scientists.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the preparation of unnatural α-amino acids and peptidomimetics.
• Agrochemical Synthesis: Used in the research and development of novel chiral active ingredients with specific biological activity.
• Asymmetric Synthesis: Serves as a substrate in stereoselective reactions, including 1,3-dipolar cycloadditions (click chemistry) and nucleophilic substitutions.
• β-Lactam Antibiotic Research: Acts as a key starting material for the synthesis of novel penicillin and cephalosporin analogs.
• Peptide Modification: Enables the site-specific introduction of azide handles for subsequent bioconjugation via click chemistry.
• Material Science: Potential monomer for creating functionalized polymers with tailored properties.

Basic Information

Product Name	(R)-Ethyl 2-Azidopropanoate
CAS No.	124988-44-9
Molecular Formula	C5H9N3O2
Molecular Weight	143.15 g/mol
Synonyms	(R)-Ethyl 2-azidopropionate; (R)-2-Azidopropionic Acid Ethyl Ester; Ethyl (R)-2-azidopropanoate; (R)-Ethyl azidoacetate; D-Ethyl 2-azidopropanoate; (R)-(-)-Ethyl 2-azidopropanoate; Azidopropanoic acid, ethyl ester, (R)-; Ethyl (R)-(-)-2-azidopropionate
EINECS	Contact for details

Quality Control

Our (R)-Ethyl 2-Azidopropanoate is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity, suitable for demanding synthetic applications. Each batch is analyzed using advanced chromatographic (HPLC, GC) and spectroscopic (NMR) techniques to confirm identity, purity, and enantiomeric excess (ee). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when possible to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.