Description

6-((tert-Butyldimethylsilyl)Oxy)Hexan-1-Amine is a protected amino alcohol derivative, serving as a versatile bifunctional building block in advanced organic synthesis. Its primary value lies in the orthogonal protection strategy it offers, where the silyl ether protects the hydroxyl group while the primary amine remains available for further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for constructing complex molecules, peptide mimetics, and active pharmaceutical ingredient (API) intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those requiring selective protection-deprotection strategies.
• Peptide Chemistry: Used to introduce spacer arms or functional handles into peptide chains and peptide mimetics.
• Linker Molecule: Employed in bioconjugation and the development of antibody-drug conjugates (ADCs) due to its reactive amine group.
• Polymer Modification: Acts as a functional monomer or chain extender for creating specialty polymers with amine functionalities.
• Ligand Synthesis: Serves as a precursor for chelating agents and catalysts used in asymmetric synthesis.
• Material Science: Utilized in surface functionalization and the creation of amine-functionalized coatings or nanomaterials.

Basic Information

Product Name	6-((tert-Butyldimethylsilyl)Oxy)Hexan-1-Amine
CAS No.	124883-99-4
Molecular Formula	C₁₂H₂₉NOSi
Molecular Weight	231.45 g/mol
Synonyms	6-((tert-Butyldimethylsilyl)oxy)hexan-1-amine; 6-[(tert-Butyldimethylsilyl)oxy]-1-hexanamine; 1-Amino-6-((tert-butyldimethylsilyl)oxy)hexane; N/A-TBDMS-6-amino-1-hexanol; 6-Aminohexyloxy-tert-butyldimethylsilane; TBDMS-protected 6-amino-1-hexanol; 6-(tert-Butyldimethylsiloxy)hexylamine
EINECS	Contact for details

Quality Control

Our 6-((tert-Butyldimethylsilyl)Oxy)Hexan-1-Amine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by techniques including HPLC, GC, and NMR. We adhere to cGMP standards where applicable, ensuring the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.