Description

L-Norvaline, 5-Hydroxy-n- [(Phenylmethoxy)Carbonyl]-, 1,1-Dimethylethylester is a protected amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a crucial chiral building block for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. Pharmaceutical research and development laboratories need it for the synthesis of novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified norvaline residues with protected side-chain functionalities.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies and enzyme-substrate interaction research.
• Proteomics & Chemical Biology: Employed in the design and synthesis of activity-based probes and labeled peptides for proteomic analysis.
• Agrochemical Development: Potential intermediate in the synthesis of specialized amino acid-derived crop protection agents.

Basic Information

Product Name	L-Norvaline, 5-Hydroxy-n- [(Phenylmethoxy)Carbonyl]-, 1,1-Dimethylethylester
CAS No.	124620-51-5
Molecular Formula	C17H25NO5
Molecular Weight	323.38 g/mol
Synonyms	5-Hydroxy-L-norvaline N-Cbz tert-butyl ester; Nα-Cbz-5-hydroxy-L-norvaline tert-butyl ester; tert-Butyl (2S)-2-{[(benzyloxy)carbonyl]amino}-5-hydroxypentanoate; N-Carbobenzoxy-5-hydroxy-L-norvaline tert-butyl ester; Cbz-5-OH-Nva-OtBu; (S)-2-((Benzyloxycarbonyl)amino)-5-hydroxypentanoic acid tert-butyl ester; Z-5-Hydroxy-L-norvaline-OtBu
EINECS	Contact for details

Quality Control

Our L-Norvaline derivative is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling. Certificates of Analysis (COA) detailing identity, assay, and related substances are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥98.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.