Description

(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8,1 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and protective silyl ether group. This compound matters as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry where precise structural control is paramount. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for developing new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel therapeutic agents, including potential antiviral or anticancer compounds.
• Organic Synthesis Research: Used in academic and industrial laboratories for methodological development and the construction of complex, polycyclic molecular frameworks.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target molecules, leveraging its protective group chemistry.
• Asymmetric Synthesis: Utilized in reactions requiring high stereoselectivity due to its defined trans configuration at the 6A position.
• Fine Chemical Production: Acts as a precursor for specialized fine chemicals used in agrochemicals or advanced material science.

Basic Information

Product Name	(6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8,1
CAS No.	124588-22-3
Molecular Formula	C₁₆H₃₂O₂Si
Molecular Weight	284.52 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]oxy-(6aR-trans)-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-6-ol; (6aR-trans)-6a,7,8,10a-Tetrahydro-6H-benzo[c]chromene-1,6-diol 1-[(1,1-Dimethylethyl)dimethylsilyl] ether; tert-Butyldimethyl((6aR,10aS)-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-yloxy)silane; TBDMS Ether of (6aR-trans)-1,6-Dihydroxy-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene; (6aR,10aS)-1-((tert-Butyldimethylsilyl)oxy)-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-6-ol
EINECS	Contact for details

Quality Control

Our (6Ar-Trans)-1-[(tert-Butyl)Dimethylsilyloxy]-6A,7,8,1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.