Description

tert-Butyldimethylsilyl (R)-(-)-Glycidyl Ether is a high-value chiral glycidyl ether derivative, widely recognized by its CAS number 124150-87-4. This compound is a critical chiral building block and protecting group reagent, prized for its ability to introduce enantiomerically pure epoxide functionality into complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high stereochemical fidelity in their synthetic routes.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material for the production of enantiomerically pure active pharmaceutical ingredients (APIs), particularly β-blockers and other cardiovascular drugs.
• Asymmetric Catalyst and Ligand Preparation: Used in the synthesis of chiral ligands and organocatalysts for stereoselective transformations.
• Advanced Polymer and Resin Chemistry: Serves as a monomer for creating chiral epoxy resins and polymers with specialized optical or mechanical properties.
• Agrochemical Intermediate: Employed in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Protecting Group for Alcohols and Diols: The TBDMS group is used to protect hydroxyl groups in multi-step organic syntheses, with the (R)-glycidyl moiety allowing for subsequent stereocontrolled ring-opening reactions.
• Fine Chemical and Flavor/Fragrance Synthesis: Used in the preparation of chiral flavor compounds and other high-value fine chemicals.

Basic Information

Product Name	tert-Butyldimethylsilyl (R)-(-)-Glycidyl Ether
CAS No.	124150-87-4
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	(R)-(-)-tert-Butyldimethylsilyl Glycidyl Ether; (R)-TBDMS Glycidyl Ether; (R)-(-)-Glycidyl tert-Butyldimethylsilyl Ether; (2R)-2-[(tert-Butyldimethylsilyl)oxymethyl]oxirane; (R)-(-)-1,2-Epoxy-3-[(tert-butyldimethylsilyl)oxy]propane; (R)-TBDSGE; TBDMS-(R)-Glycidyl Ether
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl (R)-(-)-Glycidyl Ether is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC and GC analysis, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are provided with every shipment to guarantee consistency and traceability for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation [α]20/D	-15° to -18° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.