Description

cis-3-Fluorocyclobutane-1-Carboxylic Acid is a high-value, synthetically versatile fluorinated building block. This compound is essential for medicinal chemistry and advanced materials research, where the introduction of a fluorine atom and a strained cyclobutane ring can dramatically alter the biological activity and physical properties of target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, leveraging the fluorine atom for metabolic stability and bioavailability modulation.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the fluorocyclobutane moiety can enhance activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in asymmetric catalysis and organometallic chemistry.
• Material Science: Incorporated into polymers and advanced materials to impart unique electronic or surface properties.
• Fluorine Chemistry Library: A valuable component for building blocks in high-throughput screening and combinatorial chemistry for drug discovery.
• Peptidomimetics: Used to create constrained, fluorinated amino acid analogs for probing protein structure and function.

Basic Information

Item	Details
Product Name	cis-3-Fluorocyclobutane-1-Carboxylic Acid
CAS No.	123812-78-2
Molecular Formula	C5H7FO2
Molecular Weight	118.11 g/mol
Synonyms	(1r,3s)-3-Fluorocyclobutane-1-carboxylic Acid; (1R,3S)-3-Fluorocyclobutanecarboxylic Acid; cis-3-Fluorocyclobutanecarboxylic Acid; rel-(1R,3S)-3-Fluorocyclobutanecarboxylic Acid; 3-Fluorocyclobutane-1-carboxylic Acid, cis-; Fluorocyclobutanecarboxylic Acid; 123812-78-2
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated building blocks. Production is conducted under controlled environments, and each batch is analyzed using advanced techniques like HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.