Description

1,1-Diethyl 3-Fluorocyclobutane-1,1-Dicarboxylate is a high-purity fluorinated cyclobutane derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a fluorinated cyclobutane ring and reactive ester groups, enabling precise modifications for creating novel compounds. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorinated cyclobutane moiety can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal and chemical resistance properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry for constructing complex, fluorinated ligands used in asymmetric catalysis.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the effects of fluorine substitution on cyclobutane ring systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis and scale-up projects.

Basic Information

Product Name	1,1-Diethyl 3-Fluorocyclobutane-1,1-Dicarboxylate
CAS No.	123812-76-0
Molecular Formula	C11H17FO4
Molecular Weight	232.25 g/mol
Synonyms	Diethyl 3-Fluorocyclobutane-1,1-dicarboxylate; 3-Fluorocyclobutane-1,1-dicarboxylic Acid Diethyl Ester; 1,1-Bis(ethoxycarbonyl)-3-fluorocyclobutane; 3-Fluoro-1,1-cyclobutanedicarboxylic Acid Diethyl Ester; Ethyl 3-Fluorocyclobutane-1,1-dicarboxylate; Diethyl 3-Fluorocyclobutan-1,1-dicarboxylate; 3-Fluorocyclobutan-1,1-diyldimethanol Diacetate (related form)
EINECS	Contact for details

Quality Control

Our 1,1-Diethyl 3-Fluorocyclobutane-1,1-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent lot-to-lot quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. The compound may be moisture-sensitive; handle and store under inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Impurities (HPLC)	Individual unknown ≤ 0.5%, Total ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.