Description

1-Boc-2-Trimethylsilanylpyrrolidine CAS NO 123387-66-6 is a high-purity, protected pyrrolidine derivative widely used as a critical building block in advanced organic synthesis. Its value lies in providing a versatile nitrogen-containing scaffold with orthogonal protecting groups, enabling precise and complex molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides that require specific chiral nitrogen heterocycles.
• Peptidomimetics Research: Serves as a constrained proline analog for creating stable peptide mimics in medicinal chemistry.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Custom Chemical Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	1-Boc-2-Trimethylsilanylpyrrolidine
CAS No.	123387-66-6
Molecular Formula	C12H25NO2Si
Molecular Weight	243.42 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-(trimethylsilyl)pyrrolidine; 2-Trimethylsilyl-1-Boc-pyrrolidine; N-Boc-2-(trimethylsilyl)pyrrolidine; tert-Butyl 2-(trimethylsilyl)pyrrolidine-1-carboxylate; 1-Boc-2-TMS-pyrrolidine; Pyrrolidine, 1-[(1,1-dimethylethoxy)carbonyl]-2-(trimethylsilyl)-; 2-(Trimethylsilyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Boc-2-Trimethylsilanylpyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to meet exacting customer specifications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance in GMP-related applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.