Description

1-Boc-2-Trimethylsilanylpiperidine is a high-value, protected piperidine derivative used as a critical building block in advanced organic synthesis. Its primary value lies in its dual-protecting group strategy, where the Boc group safeguards the amine and the trimethylsilyl group protects the adjacent carbon, enabling highly selective and complex multi-step reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing new active ingredients and novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing piperidine or piperazine scaffolds, such as CNS-active compounds and protease inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the protected amine functionality allows for the introduction of specific side chains.
• Peptidomimetics & PROTACs: Serves as a crucial building block for constructing peptide mimics and Proteolysis Targeting Chimeras (PROTACs) due to its orthogonal protecting groups.
• Ligand & Catalyst Development: Employed in the preparation of nitrogen-containing ligands for asymmetric catalysis and organometallic complexes.
• Material Science Research: Utilized in the synthesis of functionalized polymers and dendrimers where controlled introduction of amine groups is required.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, exploring new C-N and C-C bond-forming reactions.

Basic Information

Item	Details
Product Name	1-Boc-2-Trimethylsilanylpiperidine
CAS No.	123387-54-2
Molecular Formula	C13H27NO2Si
Molecular Weight	257.45 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-(trimethylsilyl)piperidine; 2-(Trimethylsilyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-2-(trimethylsilyl)piperidine; tert-Butyl 2-(trimethylsilyl)piperidine-1-carboxylate; 1-Boc-2-TMS-piperidine; 2-Trimethylsilyl-1-N-Boc-piperidine; 1,1-Dimethylethyl 2-(trimethylsilyl)-1-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our 1-Boc-2-Trimethylsilanylpiperidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive analytical data including HPLC, GC, NMR, and IR for identity and purity confirmation. A Certificate of Analysis (COA) detailing all specifications is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.