Description

3-Fluoro-2-Butenoic Acid Methyl Ester is a versatile fluorinated building block, a methyl ester derivative of a fluorinated unsaturated carboxylic acid. Its value lies in the strategic incorporation of fluorine and an activated double bond, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate in the synthesis of advanced active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial synthon for introducing fluorine into potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity, metabolic stability, and overall bioactivity.
• Material Science Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers and advanced materials with tailored surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in Michael addition reactions, cycloadditions, and other C-C bond-forming transformations to construct complex, fluorinated molecular architectures.
• Liquid Crystal & Electronic Chemicals: Acts as a starting material for fluorinated components used in liquid crystal displays (LCDs) and other electronic applications.

Basic Information

Product Name	3-Fluoro-2-Butenoic Acid Methyl Ester
CAS No.	123350-07-2
Molecular Formula	C5H7FO2
Molecular Weight	118.10 g/mol
Synonyms	Methyl 3-Fluoro-2-butenoate; Methyl 3-Fluorocrotonate; 3-Fluorobut-2-enoic Acid Methyl Ester; 2-Butenoic Acid, 3-Fluoro-, Methyl Ester; (E/Z)-Methyl 3-Fluoro-2-butenoate; 3-Fluorocrotonic Acid Methyl Ester; Methyl (E/Z)-3-Fluorocrotonate
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-Butenoic Acid Methyl Ester is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including GC, HPLC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place, away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatility loss.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Isomeric Ratio (E/Z) (GC)	Reported on COA
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.