Description

Ethyl 4-(Trimethylsilyloxy)-2-Butynoate is a specialized silyl-protected acetylenic ester that serves as a versatile synthetic intermediate in advanced organic synthesis. Its core value lies in enabling the controlled introduction of functionalized alkyne units into complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing key molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex acetylene or heterocyclic structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators requiring specific alkyne functionalities.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers, conductive materials, and liquid crystals.
• Organic Synthesis Reagent: Employed in Sonogashira coupling, click chemistry, and other cross-coupling reactions to install protected hydroxy-alkyne groups.
• Natural Product Synthesis: A valuable intermediate in the total synthesis of complex natural products with acetylenic bonds.
• Chemical Biology Probes: Used to create tagged molecules and probes for studying biological pathways and interactions.

Basic Information

Product Name	Ethyl 4-(Trimethylsilyloxy)-2-Butynoate
CAS No.	122850-62-8
Molecular Formula	C9H16O3Si
Molecular Weight	200.31 g/mol
Synonyms	Ethyl 4-(trimethylsilyloxy)but-2-ynoate; 2-Butynoic acid, 4-(trimethylsilyloxy)-, ethyl ester; 4-(Trimethylsilyloxy)-2-butynoic acid ethyl ester; Ethyl 4-(TMS-oxy)-2-butynoate; O-Trimethylsilyl propargylglycolic acid ethyl ester; TMS-protected propargylglycolate ethyl ester; Ethyl (3-trimethylsilyloxy)propiolate
EINECS	Contact for details

Quality Control

Our Ethyl 4-(Trimethylsilyloxy)-2-Butynoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.