Description

2-Phenyl-2-(Trimethylsilyl)Ethanol is a versatile organosilicon compound featuring both a phenyl group and a silyl-protected alcohol functionality. This unique structure makes it a valuable building block in advanced organic synthesis, particularly for the construction of complex molecules where selective protection and deprotection are required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for applications ranging from medicinal chemistry to materials science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), leveraging the silyl group as a protective moiety for the alcohol function.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective reactions to create enantiomerically pure compounds.
• Organometallic Chemistry: Acts as a ligand precursor or a modifying agent in catalytic systems and metal-organic frameworks (MOFs).
• Polymer & Material Science: Employed in the development of specialty silicones, surface-modifying agents, and advanced polymeric materials.
• Agrochemical Research: Functions as an intermediate in the design and synthesis of novel crop protection agents and herbicides.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry laboratories for studying new reaction pathways.

Basic Information

Product Name	2-Phenyl-2-(Trimethylsilyl)Ethanol
CAS No.	122760-31-0
Molecular Formula	C₁₁H₁₈OSi
Molecular Weight	194.35 g/mol
Synonyms	2-Phenyl-2-(trimethylsilyl)ethan-1-ol; α-(Trimethylsilyl)benzeneethanol; (2-Hydroxy-1-phenylethyl)trimethylsilane; 1-Phenyl-1-(trimethylsilyl)methanol (tautomeric form); 2-Phenyl-2-(TMS)ethanol; TMS-Phenyl Ethanol; 122760-31-0; Benzeneethanol, α-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Phenyl-2-(Trimethylsilyl)Ethanol is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for research and fine chemical applications. Comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, is performed to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.