Description

Pyrrolo[2,1-B]Thiazole-3-Carboxylic Acid, 6-Amino-5,6,7,7A-Tetrahydro-5-Oxo-, trans- (9Ci) is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures with potential biological activity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its defined stereochemistry and functional groups make it a valuable scaffold for medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the research and synthesis of new drug candidates, particularly for central nervous system (CNS) or anti-infective targets.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or insecticides, leveraging its unique fused ring system.
• Chemical Biology Probe Synthesis: Employed to create molecular tools for studying biological pathways and target validation.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Material Science Research: Potential precursor for the development of specialty chemicals or functional organic materials.
• Contract Research & Manufacturing (CRMO): Supplied to organizations specializing in custom synthesis and process development for clients.

Basic Information

Product Name	Pyrrolo[2,1-B]Thiazole-3-Carboxylic Acid, 6-Amino-5,6,7,7A-Tetrahydro-5-Oxo-, trans- (9Ci)
CAS No.	122716-06-7
Molecular Formula	C8H8N2O3S
Molecular Weight	212.23 g/mol
Synonyms	(3R,7aR)-6-Amino-5-oxo-3,5,6,7-tetrahydro-2H-pyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid; trans-6-Amino-5,6,7,7a-tetrahydro-5-oxo-2H-pyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid; 6-Amino-5,6,7,7a-tetrahydro-5-oxo-2H-pyrrolo[2,1-b]thiazole-3-carboxylic acid, (3R,7aR)-; Pyrrolo[2,1-b]thiazole-3-carboxylic acid, 6-amino-5,6,7,7a-tetrahydro-5-oxo-, (3R,7aR)-; 122716-06-7; (3R-trans)-6-Amino-5,6,7,7a-tetrahydro-5-oxo-2H-pyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) documenting identity, purity, chiral purity, and related substances is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.