Description

tert-Butyl 3-Methylenecyclobutanecarboxylate is a versatile and high-purity chemical intermediate featuring a reactive methylene group on a cyclobutane ring. This compound is valued for its unique steric and electronic properties, making it a critical building block in advanced organic synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug candidates, particularly those requiring constrained cyclobutane scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced activity profiles.
• Material Science Research: Acts as a monomer or precursor for developing specialty polymers with tailored thermal and mechanical properties.
• Organic Synthesis Building Block: Employed in cycloaddition reactions, cross-coupling chemistry, and other transformations to construct complex molecular architectures.
• Ligand and Catalyst Development: Utilized for creating novel chiral ligands and organocatalysts for asymmetric synthesis.
• Flavor and Fragrance Industry: Potential intermediate for synthesizing unique musk or woody odorant molecules.

Basic Information

Item	Details
Product Name	tert-Butyl 3-Methylenecyclobutanecarboxylate
CAS No.	122699-51-8
Molecular Formula	C10H16O2
Molecular Weight	168.23 g/mol
Synonyms	3-Methylenecyclobutanecarboxylic acid tert-butyl ester; tert-Butyl 3-methylidenecyclobutane-1-carboxylate; 1,1-Dimethylethyl 3-methylene-1-cyclobutanecarboxylate; 3-Methylenecyclobutanecarboxylic acid 1,1-dimethylethyl ester; TBMCB; Cyclobutane-1-carboxylic acid, 3-methylene-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Methylenecyclobutanecarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.