Description

Methyl 1-Boc-3-Pyrrolidinecarboxylate is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile, nitrogen-containing scaffold that is readily functionalized for constructing complex molecular architectures. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of various drug candidates, including protease inhibitors and neurological agents.
• Agrochemical Synthesis: Building block for developing novel pesticides and herbicides with specific stereochemical requirements.
• Peptidomimetics Research: Core structure for creating peptide analogs and mimetics in medicinal chemistry programs.
• Asymmetric Catalysis Ligand Synthesis: Starting material for the preparation of chiral ligands used in enantioselective transformations.
• Custom Chemical & Contract Manufacturing: Supplied to CDMOs for use in multi-step custom synthesis projects under cGMP conditions.
• Academic & R&D Laboratories: Used in methodological development and exploration of new heterocyclic chemistry.

Basic Information

Product Name	Methyl 1-Boc-3-Pyrrolidinecarboxylate
CAS No.	122684-33-7
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	1-Boc-3-Pyrrolidinecarboxylic Acid Methyl Ester; Methyl 3-[(tert-Butoxycarbonyl)amino]pyrrolidine-3-carboxylate; 1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic Acid Methyl Ester; tert-Butyl 3-(Methoxycarbonyl)pyrrolidine-1-carboxylate; 3-Carbomethoxy-1-Boc-pyrrolidine; 1-N-Boc-3-Carbomethoxypyrrolidine; Boc-3-Pyrrolidine Methyl Ester; 122684-33-7
EINECS	Contact for details

Quality Control

Our Methyl 1-Boc-3-Pyrrolidinecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong acids and oxidizing agents. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.