Description

n-Succinimidyl-2-Methoxy 2-Phenylacetic Acid Ester is a high-purity, activated ester derivative used as a critical bioconjugation reagent. Its primary value lies in its ability to efficiently form stable amide bonds with primary amines under mild aqueous conditions, making it indispensable for modifying biomolecules. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require reliable and specific crosslinking agents for protein labeling, antibody-drug conjugate (ADC) development, and peptide synthesis.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: A key intermediate for attaching cytotoxic payloads to monoclonal antibodies via lysine residues.
• Protein and Peptide Labeling: Conjugation of fluorescent dyes, biotin, or other probes to proteins for imaging, detection, and assay development.
• Biomolecule Immobilization: Functionalization of surfaces, beads, or chips with proteins or peptides for biosensor and microarray fabrication.
• Polymer Modification: Introducing bioactive ligands or functional groups onto polymeric materials for biomedical applications.
• Diagnostic Reagent Synthesis: Production of enzyme conjugates and other labeled reagents used in immunoassays (ELISA, lateral flow tests).
• Chemical Biology Tool: Used in probe development for studying protein function and interactions in research settings.

Basic Information

Product Name	n-Succinimidyl-2-Methoxy 2-Phenylacetic Acid Ester
CAS No.	122607-12-9
Molecular Formula	C13H13NO6
Molecular Weight	279.25 g/mol
Synonyms	2-Methoxy-2-phenylacetic acid N-hydroxysuccinimide ester; α-Methoxyphenylacetic acid N-succinimidyl ester; NHS ester of 2-methoxy-2-phenylacetic acid; O-(N-Succinimidyl)-2-methoxy-2-phenylacetate; S-2-Methoxy-2-phenylacetic acid succinimidyl ester; Atrolactic acid α-methyl ether N-succinimidyl ester; NSC 405124
EINECS	Contact for details

Quality Control

Our n-Succinimidyl-2-Methoxy 2-Phenylacetic Acid Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the stringent requirements for bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.