Description

4-Azido-2,3,5,6-Tetrafluorobenzoic Acid is a highly functionalized aromatic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an azido group and a perfluorinated benzoic acid core, makes it a versatile precursor for click chemistry and the development of novel materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to incorporate fluorine and bioorthogonal handles into their molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and for introducing bioorthogonal azide groups for targeted drug delivery systems.
• Agrochemical Research: Used in developing novel fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Click Chemistry Reagent: Serves as a vital component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer functionalization, and material surface modification.
• Polymer & Material Science: Building block for synthesizing specialty fluoropolymers, coatings, and high-performance materials with unique thermal, chemical, and surface properties.
• Ligand & Catalyst Development: Used to create novel ligands and organocatalysts where the electron-withdrawing tetrafluoro and azido groups modulate reactivity and selectivity.
• Diagnostic & Imaging Agent Synthesis: Intermediate for developing fluorinated probes and contrast agents used in medical imaging techniques like PET and MRI.

Basic Information

Item	Detail
Product Name	4-Azido-2,3,5,6-Tetrafluorobenzoic Acid
CAS No.	122590-77-6
Molecular Formula	C7HF4N3O2
Molecular Weight	235.10 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-azidobenzoic Acid; 4-Azidotetrafluorobenzoic Acid; Perfluoro-4-azidobenzoic Acid; Benzoic acid, 4-azido-2,3,5,6-tetrafluoro-; 4-N3-Tetrafluorobenzoic Acid; 4-Azido-TFBA; Azido-TFBA; TFBA-Azide
EINECS	Contact for details

Quality Control

Our 4-Azido-2,3,5,6-Tetrafluorobenzoic Acid is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and FT-IR for functional group verification. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.