Description

1-Pyrrolidinecarboxylic Acid, 3-[(Methylsulfonyl)Oxy]-, Phenylmethyl Ester, (3S)- is a high-purity chiral building block and synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is valued for its role in constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and other bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and protease inhibitors due to its pyrrolidine carboxylic acid ester backbone.
• Asymmetric Synthesis: Serves as a starting material or intermediate in stereoselective reactions to introduce the (3S) chiral center into target molecules.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the development of new chemical entities for various therapeutic targets.
• Process Chemistry: Utilized in route scouting and scale-up optimization for the commercial manufacturing of specialty chemicals and pharmaceuticals.
• Bioconjugation & Labeling: The reactive methylsulfonyloxy (mesylate) group can be leveraged for further functionalization and bioconjugation strategies.

Basic Information

Item	Details
Product Name	1-Pyrrolidinecarboxylic Acid, 3-[(Methylsulfonyl)Oxy]-, Phenylmethyl Ester, (3S)-
CAS No.	122536-69-0
Molecular Formula	C14H17NO5S
Molecular Weight	311.35 g/mol
Synonyms	(3S)-3-[(Methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid phenylmethyl ester; (S)-Benzyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate; (S)-Benzyl 3-(mesyloxy)pyrrolidine-1-carboxylate; (S)-Cbz-3-mesyloxypyrrolidine; (3S)-1-(Benzyloxycarbonyl)-3-(methylsulfonyloxy)pyrrolidine; (S)-1-Cbz-3-(OMs)pyrrolidine; (S)-N-Cbz-3-Hydroxypyrrolidine Mesylate Ester
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-[(Methylsulfonyl)Oxy]-, Phenylmethyl Ester, (3S)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for research and development. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.