Description

(R)-2-Benzyl-4-tert-Butoxy-4-Oxobutanoic Acid CAS NO 122225-33-6 is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its well-defined stereochemistry and functional groups, which are critical for constructing complex molecules with precise three-dimensional architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Serves as a crucial building block for constructing complex, enantiomerically pure molecules via stereoselective reactions.
• Peptidomimetics & Prodrug Development: Used in the design and synthesis of peptide analogs and prodrugs due to its carboxylic acid and protected ester functionalities.
• Catalyst & Ligand Synthesis: Acts as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & Industrial R&D: Employed in research laboratories for methodological studies in organic chemistry and process development.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.

Basic Information

Product Name	(R)-2-Benzyl-4-tert-Butoxy-4-Oxobutanoic Acid
CAS No.	122225-33-6
Molecular Formula	C15H20O4
Molecular Weight	264.32 g/mol
Synonyms	(R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid; (R)-2-Benzyl-4-(tert-Butoxycarbonyl)butanoic Acid; (R)-2-Benzyl-4-(Boc-amino)butanoic Acid (common misnomer); (R)-2-Benzylsuccinic Acid 4-tert-Butyl Ester; (R)-4-(tert-Butoxy)-2-benzyl-4-oxobutanoic Acid; (R)-Benzyl-Boc-GABA (analog); (R)-H-Glu(OtBu)-OH (benzyl substituted analog); (2R)-2-Benzyl-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid (IUPAC)
EINECS	Contact for details

Quality Control

Our (R)-2-Benzyl-4-tert-Butoxy-4-Oxobutanoic Acid is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Each batch is analyzed using advanced techniques including HPLC, GC, and chiral analysis to confirm identity, potency, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.