Description

L-Threo-Hex-2-Enaric Acid, 1,4-Lactone, 6-Methyl Ester is a specialized chiral lactone derivative with a defined stereochemistry, making it a valuable building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of complex molecules, particularly in the pharmaceutical and agrochemical sectors where precise stereochemical control is critical. It is needed by research institutions and industrial R&D teams focused on developing new active ingredients, flavors, and fragrances.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting metabolic and neurological pathways.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides with specific stereoisomeric activity.
• Flavor & Fragrance (F&F) Industry: Serves as a precursor for creating unique lactone-based aroma compounds and flavor enhancers.
• Organic Synthesis: A versatile building block for constructing complex natural product analogs and other fine chemicals.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with tailored properties.
• Academic & Contract Research: Essential for methodological studies in asymmetric synthesis and catalysis.

Basic Information

Product Name	L-Threo-Hex-2-Enaric Acid, 1,4-Lactone, 6-Methyl Ester
CAS No.	122046-79-1
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	6-Methyl L-threo-hex-2-enaro-1,4-lactone; Methyl 6-methyl-2,3,4,5-tetrahydro-2H-pyran-2-carboxylate (stereospecific); (2S,3S)-6-Methyl-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester; L-Threo configuration lactone ester; Hex-2-enaric acid lactone methyl ester; Chiral δ-lactone derivative; (2S,3S)-rel-6-Methyl-3,4-dihydro-2H-pyran-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of L-Threo-Hex-2-Enaric Acid, 1,4-Lactone, 6-Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Optical Rotation [α]	Specific range provided on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.