Description

1-tert-Butyl 2-Methyl 3-Oxopiperidine-1,2-Dicarboxylate is a high-purity, protected piperidine derivative serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex molecules with precise stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel APIs, particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the piperidinone scaffold with defined stereocenters.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and synthesis of peptide mimics for drug discovery programs.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides and fungicides that require specific nitrogen heterocycle motifs.
• Catalyst and Ligand Development: Used as a precursor for creating novel chiral catalysts and ligands used in organic synthesis.
• Academic & Institutional Research: Employed in methodological studies and the exploration of new synthetic routes to complex natural products.

Basic Information

Product Name	1-tert-Butyl 2-Methyl 3-Oxopiperidine-1,2-Dicarboxylate
CAS No.	122019-53-8
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-methyl 3-oxopiperidine-1,2-dicarboxylate; 3-Oxo-1-piperidinecarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester; 1-Boc-2-methyl 3-oxopiperidine-1,2-dicarboxylate; tert-Butyl methyl 3-oxopiperidine-1,2-dicarboxylate; Methyl 1-(tert-butoxycarbonyl)-3-oxopiperidine-2-carboxylate; 3-Oxopipecolic acid 1-tert-butyl 2-methyl ester; 122019-53-8; Boc-3-oxo-L-pipecolic acid methyl ester (stereoisomer specific)
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 2-Methyl 3-Oxopiperidine-1,2-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are available for every lot to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.