Description

Methyl (3R)-3-{[(tert-Butyl)(Dimethyl)Silyl]Oxy}Hex-5-Enoate is a high-purity chiral building block and protected alcohol intermediate essential for advanced organic synthesis. Its value lies in providing a stereochemically defined handle for constructing complex molecules, enabling precise control in multi-step synthetic routes. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the production of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of prostaglandins, leukotrienes, and other bioactive molecules with defined stereochemistry.
• Agrochemical Synthesis: Building block for creating advanced, stereoselective pesticides and herbicides.
• Fine Chemical Production: Used in the manufacture of flavors, fragrances, and specialty chemicals requiring high enantiomeric purity.
• Academic & Industrial R&D: Serves as a versatile starting material in methodological development and route scouting for complex natural product synthesis.
• Peptide Mimetics & Prodrug Development: The silyl-protected hydroxy ester functionality is useful for constructing peptide analogs and designing prodrugs.
• Material Science Precursor: Potential intermediate for synthesizing specialized monomers for polymers with specific chiral properties.

Basic Information

Product Name	Methyl (3R)-3-{[(tert-Butyl)(Dimethyl)Silyl]Oxy}Hex-5-Enoate
CAS No.	121980-44-7
Molecular Formula	C₁₃H₂₆O₃Si
Molecular Weight	258.43 g/mol
Synonyms	(R)-Methyl 3-((tert-butyldimethylsilyl)oxy)hex-5-enoate; Methyl (3R)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-5-hexenoate; (R)-3-[(tert-Butyldimethylsilyl)oxy]hex-5-enoic Acid Methyl Ester; TBDMS-protected (R)-5-Hexen-3-ol Methyl Ester; (3R)-3-[(tert-Butyldimethylsilyl)oxy]hex-5-enoic Acid Methyl Ester; (R)-Methyl 3-(TBDMSO)hex-5-enoate
EINECS	Contact for details

Quality Control

Our Methyl (3R)-3-{[(tert-Butyl)(Dimethyl)Silyl]Oxy}Hex-5-Enoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.