Description

Per-o-Acetyl-α-Thioethyl-n-Acetylneuraminic Methyl Ester CAS NO 121512-91-2 is a sophisticated, high-purity synthetic intermediate derived from sialic acid, a critical biomolecule. This compound is essential for the chemical and enzymatic synthesis of sialylated glycoconjugates, enabling precise research and development in glycobiology. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutics, vaccines, and diagnostic tools.

Application

• Glycoconjugate Synthesis: A key building block for the chemical and chemoenzymatic synthesis of sialylated oligosaccharides, glycopeptides, and glycolipids.
• Pharmaceutical Research: Used in the development of sialidase inhibitors, anti-influenza drugs, and other therapeutics targeting cell-surface carbohydrate interactions.
• Vaccine Development: Serves as a critical intermediate for creating synthetic carbohydrate antigens for conjugate vaccines against bacterial pathogens.
• Biochemical Tool: Employed in enzymatic trans-sialylation reactions to study sialyltransferase activity and for labeling biomolecules.
• Diagnostic Reagent Production: Used to synthesize probes and standards for detecting and quantifying sialic acid derivatives in clinical and research settings.
• Glycoengineering: Facilitates the study of cell-surface glycan remodeling and its role in cell signaling, immune response, and disease progression.

Basic Information

Item	Detail
Product Name	Per-o-Acetyl-α-Thioethyl-n-Acetylneuraminic Methyl Ester
CAS No.	121512-91-2
Molecular Formula	C22H33NO13S
Molecular Weight	551.56 g/mol
Synonyms	Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-D-galacto-non-2-ulopyranosonate; Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranosid)onate; Sialic Acid Thioethyl Ester Derivative; Peracetylated Sialyl Donor; α-Thioethyl Sialoside Donor; Neu5AcαSEt Peracetate Methyl Ester; 2-Thioethyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosidonic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Per-o-Acetyl-α-Thioethyl-n-Acetylneuraminic Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.