Description

(1Alpha,5Alpha,6Alpha)-2-Oxabicyclo[3.1.0]Hex-3-Ene-3,6-Dicarboxylic Acid 3-Ethyl 6-Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex bicyclic oxabicyclo structure. This compound is critical for enabling sophisticated synthetic routes in medicinal chemistry, offering a versatile chiral scaffold for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to construct molecules with high enantiomeric purity.
• Process Chemistry Development: Employed in the scale-up and route scouting for the commercial manufacturing of advanced intermediates.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	(1Alpha,5Alpha,6Alpha)-2-Oxabicyclo[3.1.0]Hex-3-Ene-3,6-Dicarboxylic Acid 3-Ethyl 6-Methyl Ester
CAS No.	121262-20-2
Molecular Formula	C11H12O5
Molecular Weight	224.21 g/mol
Synonyms	3-Ethyl 6-methyl (1α,5α,6α)-2-oxabicyclo[3.1.0]hex-3-ene-3,6-dicarboxylate; 2-Oxabicyclo[3.1.0]hex-3-ene-3,6-dicarboxylic acid, 3-ethyl 6-methyl ester, (1α,5α,6α)-; Ethyl methyl (1α,5α,6α)-2-oxabicyclo[3.1.0]hex-3-ene-3,6-dicarboxylate; Bicyclic Oxabicyclo Ester Intermediate; CAS 121262-20-2
EINECS	Contact for details

Quality Control

Our production of (1Alpha,5Alpha,6Alpha)-2-Oxabicyclo[3.1.0]Hex-3-Ene-3,6-Dicarboxylic Acid 3-Ethyl 6-Methyl Ester adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity limits is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the material from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.