Description

(2S-Trans)-4-Azido-1,2-Pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester is a high-purity, chiral azido-pyrrolidine derivative, a crucial building block in advanced organic synthesis. Its value lies in its unique stereochemistry and reactive azide functionality, enabling the construction of complex, nitrogen-containing molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and for applications in click chemistry and bioconjugation.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other biologically active molecules.
• Peptidomimetic Research: Used to introduce constrained pyrrolidine scaffolds and azide handles into peptide analogs to modulate stability and activity.
• Click Chemistry Substrate: The azide group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for efficient bioconjugation and polymer functionalization.
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Material Science: Employed in the synthesis of functionalized polymers and dendrimers with tailored properties.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and protein labeling.

Basic Information

Product Name	(2S-Trans)-4-Azido-1,2-Pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester
CAS No.	121147-97-5
Molecular Formula	C12H18N4O4
Molecular Weight	282.30 g/mol
Synonyms	(2S,4S)-4-Azido-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid methyl ester; tert-Butyl (2S,4S)-4-azido-2-(methoxycarbonyl)pyrrolidine-1-carboxylate; Boc-4-Azido-L-proline methyl ester (trans); (2S,4S)-1-Boc-4-azidoproline methyl ester; trans-4-Azido-L-proline(1-Boc, 2-OMe); 4-Azido-L-proline derivative (Boc, OMe, trans); 1-Boc-4-azido-trans-L-proline methyl ester; L-Proline, 4-azido-, 1,2-diethyl ester, 1-(1,1-dimethylethyl) ester, (2S-trans)-
EINECS	Contact for details

Quality Control

Our production of (2S-Trans)-4-Azido-1,2-Pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized by NMR, HPLC, and chiral analysis to confirm identity, stereochemical purity, and potency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.