Description

(2S,4S)-1-tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering precise stereochemical control essential for developing active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Serves as a crucial starting material or intermediate in stereoselective reactions to construct molecules with defined three-dimensional architecture.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and synthetic chemistry.

Basic Information

Item	Details
Product Name	(2S,4S)-1-tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate
CAS No.	121147-94-2
Molecular Formula	C18H23NO6
Molecular Weight	349.38 g/mol
Synonyms	(2S,4S)-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-4-(benzoyloxy)pyrrolidine; 1-Boc-4-benzoyloxy-L-proline methyl ester; (2S,4S)-1-Boc-4-(benzoyloxy)proline methyl ester; 1-tert-Butyl 2-methyl (2S,4S)-4-(benzoyloxy)pyrrolidine-1,2-dicarboxylate; (2S,4S)-4-Benzoyloxyproline methyl ester N-Boc derivative; L-Proline, 4-(benzoyloxy)-1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, (4S)-; (4S)-1-{[(tert-Butoxy)carbonyl]}-4-(benzoyloxy)-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our (2S,4S)-1-tert-Butyl 2-Methyl 4-(Benzoyloxy)Pyrrolidine-1,2-Dicarboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.