Description

4-Isothiocyanate-Piretanide is a high-purity chemical intermediate, specifically a functionalized derivative of the loop diuretic piretanide. This compound is valued for its reactive isothiocyanate group, which enables its use as a key building block in the synthesis of more complex molecules, particularly for research and pharmaceutical development. It is essential for scientists and manufacturers in the pharmaceutical and life science sectors who require precise, reliable intermediates for advanced chemical synthesis and biochemical labeling studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the research and development of novel diuretic agents or piretanide analogs.
• Bioconjugation & Labeling Reagent: The reactive isothiocyanate group allows for covalent attachment to proteins, antibodies, or other biomolecules containing amine groups for diagnostic or research purposes.
• Chemical Biology Research: Used in proteomics and target identification studies to investigate biological pathways and protein function.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Organic Synthesis Building Block: Employed in medicinal chemistry for the creation of targeted compound libraries and structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Isothiocyanate-Piretanide
CAS No.	120749-13-5
Molecular Formula	C₁₇H₁₈N₄O₅S₂
Molecular Weight	422.48 g/mol
Synonyms	4-Isothiocyanato-Piretanide; Piretanide 4-Isothiocyanate; 3-(Phenylsulfamoyl)-4-phenoxy-5-sulfamoylbenzoic Acid 4-Isothiocyanate; 4-Isothiocyanato-3-(phenylsulfamoyl)-4-phenoxy-5-sulfamoylbenzoic Acid; Benzoic acid, 4-isothiocyanato-3-(phenylsulfamoyl)-4-phenoxy-5-sulfamoyl-; Piretanide Isothiocyanate Derivative
EINECS	Contact for details

Quality Control

Our 4-Isothiocyanate-Piretanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.