Description

2-(Trimethylsilyl)Oxazole is a versatile organosilicon building block and a key reagent in modern synthetic chemistry. Its value lies in its ability to act as a protected or masked oxazole synthon, facilitating the construction of complex heterocyclic compounds under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediates: A crucial building block for the synthesis of complex drug candidates, particularly those containing oxazole or related heterocyclic cores.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the oxazole moiety can impart specific biological activity.
• Material Science Precursor: Serves as a starting material for creating specialized polymers, ligands, or silicon-containing advanced materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions, such as Suzuki or Stille couplings, for carbon-carbon bond formation.
• Nucleoside & Peptide Mimetics: Employed in the synthesis of modified nucleosides or peptide analogs for medicinal chemistry and biochemical research.
• Protecting Group Strategy: The trimethylsilyl group can be used as a temporary protecting group for the oxazole nitrogen in multi-step synthetic sequences.

Basic Information

Product Name	2-(Trimethylsilyl)Oxazole
CAS No.	120629-79-0
Molecular Formula	C6H11NOSi
Molecular Weight	141.24 g/mol
Synonyms	2-(Trimethylsilyl)-1,3-oxazole; Oxazole, 2-(trimethylsilyl)-; 2-TMS-oxazole; 2-Trimethylsilyloxazole; 2-(Trimethylsilyl)oxazole; 2-(Trimethylsilyl)-oxazole; 2-(TMS)Oxazole; 2-Oxazolyltrimethylsilane
EINECS	Contact for details

Quality Control

Every batch of 2-(Trimethylsilyl)Oxazole is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our quality assurance system is designed to meet the stringent requirements of research and development as well as scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC or HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.