Description

4-[(tert-Butyldimethylsilyl)Oxy]Butan-2-One is a specialized organosilicon-protected derivative of butan-2-one, widely utilized as a key synthetic intermediate in advanced organic synthesis. Its primary value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which offers exceptional stability under a wide range of reaction conditions while being selectively removable. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, where it facilitates the precise construction of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for protecting hydroxyl groups during complex transformations.
• Agrochemical Synthesis: Used in the development and production of advanced pesticides, herbicides, and plant growth regulators requiring selective protection/deprotection strategies.
• Fine Chemical Production: Serves as a versatile reagent for the synthesis of flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial R&D: A valuable tool in research laboratories for methodology development and the exploration of new synthetic pathways in organic chemistry.
• Peptide & Nucleoside Chemistry: Employed in the protection of sensitive functional groups during the synthesis of complex biomolecules.

Basic Information

Product Name	4-[(tert-Butyldimethylsilyl)Oxy]Butan-2-One
CAS No.	120591-36-8
Molecular Formula	C10H22O2Si
Molecular Weight	202.37 g/mol
Synonyms	4-(tert-Butyldimethylsilyloxy)-2-butanone; 4-(TBDMSO)-2-Butanone; 1-(tert-Butyldimethylsilyloxy)-3-butanone; 3-Oxobutyl tert-butyldimethylsilyl ether; 4-(tert-Butyldimethylsiloxy)butan-2-one; TBDMS ether of 4-hydroxy-2-butanone; 4-Hydroxy-2-butanone TBDMS ether
EINECS	Contact for details

Quality Control

Every batch of 4-[(tert-Butyldimethylsilyl)Oxy]Butan-2-One is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.