Description

[R,S]-tert-Butyl 3-Amino-2-Methylpropionate CAS NO 120378-12-3 is a versatile chiral building block and protected amino acid derivative essential for advanced organic synthesis. Its value lies in providing a sterically hindered tert-butyl ester group, which offers superior stability under basic conditions and facilitates selective deprotection in complex multi-step sequences. This compound is critically needed by pharmaceutical R&D and fine chemical manufacturers for constructing active pharmaceutical ingredients (APIs), peptides, and other high-value specialty chemicals where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other small molecule therapeutics.
• Peptide Chemistry: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis, enabling the incorporation of modified amino acid residues.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce chiral centers with high enantiomeric purity.
• Agrochemical Research: Building block for developing novel chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Precursor for creating novel chiral ligands and organocatalysts used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing custom molecules for client projects.

Basic Information

Product Name	[R,S]-tert-Butyl 3-Amino-2-Methylpropionate
CAS No.	120378-12-3
Molecular Formula	C9H19NO2
Molecular Weight	173.25 g/mol
Synonyms	3-Amino-2-methylpropanoic acid tert-butyl ester; tert-Butyl 3-amino-2-methylpropionate; DL-tert-Butyl 3-amino-2-methylpropanoate; (±)-tert-Butyl 3-amino-2-methylpropionate; 2-Methyl-3-aminopropionic acid tert-butyl ester; β-Amino-α-methylpropionic acid tert-butyl ester; tert-Butyl β-amino-α-methylpropionate
EINECS	Contact for details

Quality Control

Our [R,S]-tert-Butyl 3-Amino-2-Methylpropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets exacting standards for research and production. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, impurity profile, and physical characteristics, supporting compliance in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.