Description

Phosphonic Acid, [[1-[[(Methylsulfonyl)Oxy]Methyl]-2-(Phenylmethoxy)Ethoxy]Methyl]-, Diethyl Ester-R is a specialized organophosphorus compound with a complex molecular architecture, serving as a high-value synthetic intermediate. Its structure, featuring a phosphonic acid diethyl ester core protected by a benzyloxymethyl (BOM) and a mesylate-leaving group, makes it a critical building block for constructing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, prodrugs, and functional materials. Its controlled reactivity profile allows for selective transformations, enabling the creation of sophisticated chemical libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for constructing phosphate or phosphonate prodrugs and nucleotide analogs.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and plant growth regulators that utilize phosphonate chemistry.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating activity-based probes, enzyme inhibitors, and tools for studying phosphorylation pathways.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and flame-retardant materials.
• Catalyst & Ligand Synthesis: Utilized for preparing sophisticated phosphonate-based ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	Phosphonic Acid, [[1-[[(Methylsulfonyl)Oxy]Methyl]-2-(Phenylmethoxy)Ethoxy]Methyl]-, Diethyl Ester-R
CAS No.	120362-30-3
Molecular Formula	C16H27O8PS
Molecular Weight	410.41 g/mol
Synonyms	[[(Benzyloxymethoxy)ethoxy]methyl]phosphonic Acid Diethyl Ester Mesylate; Diethyl [[1-[(Methylsulfonyl)oxy]-2-(phenylmethoxy)ethoxy]methyl]phosphonate; (Benzyloxymethoxyethoxy)methylphosphonic Acid Diethyl Ester Mesylate; Diethyl (BOM-Protected Hydroxymethyl)phosphonate Mesylate; Phosphonic Acid, P-[[1-[(Methylsulfonyl)oxy]-2-(phenylmethoxy)ethoxy]methyl]-, Diethyl Ester; 120362-30-3; BOM-Protected Phosphonate Mesylate Ester
EINECS	Contact for details

Quality Control

Every batch of Phosphonic Acid, [[1-[[(Methylsulfonyl)Oxy]Methyl]-2-(Phenylmethoxy)Ethoxy]Methyl]-, Diethyl Ester-R is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR (1H, 13C, 31P), HPLC, and mass spectrometry. Our commitment to cGMP standards for advanced intermediates ensures the material is suitable for demanding R&D and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.