Description

(2S)-3-{[tert-Butyl(Diphenyl)Silyl]Oxy}-2-Methyl-1-Propanol CAS NO 120346-83-0 is a high-purity, chiral organosilicon-protected alcohol intermediate of significant importance in advanced synthetic chemistry. Its primary value lies in its role as a key building block for the stereoselective synthesis of complex pharmaceutical molecules and fine chemicals. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-fidelity chiral intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and metabolic disorders.
• Asymmetric Synthesis: Utilized in the construction of stereogenic centers for complex natural products and bioactive molecules, leveraging its protected hydroxyl and chiral methyl group.
• Peptidomimetics & Prodrug Development: Serves as a scaffold or side-chain component in the design of peptide analogs and prodrugs to enhance bioavailability and metabolic stability.
• Ligand & Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and organometallic complexes.
• Agrochemical Synthesis: Employed in the research and production of chiral herbicides, fungicides, and plant growth regulators.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers with tailored properties.

Basic Information

Product Name	(2S)-3-{[tert-Butyl(Diphenyl)Silyl]Oxy}-2-Methyl-1-Propanol
CAS No.	120346-83-0
Molecular Formula	C20H28O2Si
Molecular Weight	328.53 g/mol
Synonyms	(S)-3-[(tert-Butyldiphenylsilyl)oxy]-2-methyl-1-propanol; (2S)-3-[(tert-Butyldiphenylsilyl)oxy]-2-methylpropan-1-ol; (S)-TBDPS-O-2-Methylpropanol; (S)-2-Methyl-3-(tert-butyldiphenylsilyloxy)-1-propanol; tert-Butyl((2S)-2-methyl-3-hydroxypropoxy)diphenylsilane; (S)-TBDPS Protected 2-Methyl-1,3-propanediol derivative; Chiral TBDPS ether alcohol
EINECS	Contact for details

Quality Control

Our (2S)-3-{[tert-Butyldiphenylsilyl]oxy}-2-methyl-1-propanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.