Description

2,3-Pyridinedicarboxylic Acid, 5-(Trifluoromethyl)-, Diethyl Ester is a high-value, fluorinated pyridine derivative that serves as a critical synthetic intermediate. Its core value lies in the unique reactivity imparted by the trifluoromethyl group and ester functionalities, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require advanced building blocks for drug discovery and active ingredient synthesis. Its specific structure makes it a key precursor for creating complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as electron-transport layers or fluorinated polymers for specialized coatings.
• Chemical Biology Probes: Utilized to synthesize fluorescent tags or molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Scale-up: A vital starting material for contract research and manufacturing organizations (CROs/CMOs) providing bespoke chemical synthesis services.

Basic Information

Product Name	2,3-Pyridinedicarboxylic Acid, 5-(Trifluoromethyl)-, Diethyl Ester
CAS No.	120083-60-5
Molecular Formula	C12H12F3NO4
Molecular Weight	291.23 g/mol
Synonyms	Diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate; 5-(Trifluoromethyl)pyridine-2,3-dicarboxylic Acid Diethyl Ester; 2,3-Pyridinedicarboxylic acid, 5-(trifluoromethyl)-, diethyl ester; 5-Trifluoromethyl-2,3-pyridinedicarboxylic Acid Diethyl Ester; 5-CF3-Pyridine-2,3-dicarboxylic Acid Diethyl Ester; 2,3-Diethoxycarbonyl-5-trifluoromethylpyridine; 5-Trifluoromethyl-2,3-di(ethoxycarbonyl)pyridine
EINECS	Contact for details

Quality Control

Our 2,3-Pyridinedicarboxylic Acid, 5-(Trifluoromethyl)-, Diethyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.