Description

(R)-2-(1-Naphthylmethyl)-Succinic Acid-1-Methyl Ester CAS NO 119807-82-8 is a chiral, non-racemic organic compound featuring a succinic acid ester core substituted with a 1-naphthylmethyl group. This specific stereochemistry makes it a valuable chiral building block and intermediate in asymmetric synthesis. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries. The compound's structure is ideal for constructing complex molecules where stereochemical control is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) agents and other therapeutic compounds.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce stereocenters with high enantiomeric purity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.
• Academic and Industrial Research: A valuable tool for methodological development in organic chemistry and for probing structure-activity relationships (SAR).

Basic Information

Product Name	(R)-2-(1-Naphthylmethyl)-Succinic Acid-1-Methyl Ester
CAS No.	119807-82-8
Molecular Formula	C₁₇H₁₈O₄
Molecular Weight	286.32 g/mol
Synonyms	(R)-2-[(1-Naphthyl)methyl]butanedioic acid 1-methyl ester; Methyl (R)-2-[(naphthalen-1-yl)methyl]succinate; (R)-Methyl 2-(1-naphthylmethyl)succinate; (R)-1-Methoxy-1-oxo-4-((1-naphthyl)methyl)butan-2-yl; Succinic acid, 2-(1-naphthylmethyl)-, methyl ester, (R)-; (2R)-2-[(1-Naphthyl)methyl]butanedioic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-2-(1-Naphthylmethyl)-Succinic Acid-1-Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and IR spectroscopy for structural confirmation. We provide Certificates of Analysis (COA) detailing purity, identity, and chiral purity specifications to ensure it meets the rigorous standards required for pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.