Description

Methyl 2-Hydroxy-5-[2-(Trimethylsilyl)Ethynyl]-Benzenecarboxylate CAS NO 119754-18-6 is a specialized aromatic ester derivative featuring both a phenolic hydroxyl group and a trimethylsilyl-protected ethynyl moiety. This unique bifunctional structure makes it a valuable advanced intermediate for synthesizing complex organic molecules, particularly in pharmaceutical and materials science research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring Sonogashira coupling or other cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or precursor for conjugated polymers, organic semiconductors, and liquid crystals due to its ethynyl functionality.
• Organic Synthesis Reagent: Employed in academic and industrial labs for constructing complex aromatic systems and natural product analogs.
• Protecting Group Strategy: The trimethylsilyl (TMS) group can be used as a protective handle for the alkyne, allowing for selective functionalization at other sites on the molecule.
• Ligand and Catalyst Development: Potential starting material for creating novel ligands used in homogeneous catalysis.

Basic Information

Product Name	Methyl 2-Hydroxy-5-[2-(Trimethylsilyl)Ethynyl]-Benzenecarboxylate
CAS No.	119754-18-6
Molecular Formula	C13H16O3Si
Molecular Weight	248.35 g/mol
Synonyms	Methyl 5-((Trimethylsilyl)ethynyl)salicylate; 2-Hydroxy-5-[(trimethylsilyl)ethynyl]benzoic Acid Methyl Ester; Methyl 5-(2-Trimethylsilylethynyl)-2-hydroxybenzoate; Benzoic acid, 2-hydroxy-5-[(trimethylsilyl)ethynyl]-, methyl ester; Methyl 2-hydroxy-5-((trimethylsilyl)ethynyl)benzoate; TMS-Ethynyl Salicylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Hydroxy-5-[2-(Trimethylsilyl)Ethynyl]-Benzenecarboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a cGMP-compliant quality management system suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.